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Preethi G. Pai , P. Umma Habeeba , Sheetal Ullal , P. Ahsan Shoeb , M. S. Pradeepti , Ramya

Abstract

Lycium barbarum L. Solanaceae a traditional medicinal plant of China has been accorded a very high safety value. It has been known to possess various beneficial effects like reduction of blood glucose and serum lipids in alloxan-induced diabetes models, anti-ageing, immuno-modulating, anti-cancer, anti-fatigue, and male fertility-facilitatory actions. The present study is an attempt to explore the hypolipidemic effects of powdered L. barbarum in high fat diet-induced model of hyperlipidemia. Powdered L. barbarum fruit extract (250mg/kg and 500mg/kg) was administered to Wistar albino rats fed on a cholesterol-rich high-fat diet for 45 days. The effects were compared with the standard drug atorvastatin (10 mg/kg/day, oral). After 30 days of treatment, the lipid profile of the blood samples of the experimental rodents was evaluated.The data presented as mean±SEM were analysed using one-way ANOVA followed by Tukey's post hoc test. P<0.05 was considered as statistically significant. In the present study, L. barbarum powdered extract showed a significant reducti on in the total cholesterol, triglycerides and very low density lipoprotein-cholesterol levels at both the doses employed (p<0.05). However, reduction in low density lipoprotein-cholesterol levels was significant (p<0.05) only at the dose of 500 mg/kg when compared to the standard drug group. The increase in high-density lipoprotein levels was significant only at 250 mg/kg. The data thus suggests the positive anti -hyperlipidemic activity of L. barbarum in high fat diet-induced hyperlipidemia in rats.

Keywords

Goji berry, Hypolipidemic activity, High-fat diet, Lyciumbarbarum

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D. Vandana ¹, Nithya Anand ², Deepika Kalicheti ³, Bagavad Gita ⁴, Preethe Paddmanaban ⁵, Ramya ⁵

Affiliations
1 Department of Periodontology, Sree Balaji Dental College & Hospital, BIHER, Chennai, IN
2 Professor, Department of Periodontology, Sree Balaji Dental College & Hospital, BIHER, Chennai, IN
3 Post Graduate Student, Department of Periodontology, Sree Balaji Dental College & Hospital, BIHER, Chennai, IN
4 Professor & Head, Department of Periodontology, Sree Balaji Dental College & Hospital, BIHER, Chennai, IN
5 Reader, Department of Periodontology, Sree Balaji Dental College & Hospital, BIHER, Chennai, IN

Abstract

Background: The Anaemia of chronic disease (ACD) is a prevalent, poorly understood condition that afflicts patients with a wide variety of diseases, including infections, malignancies and rheumatologic disorders.

Materials and Method: 40 patients 20-65 years of age with chronic periodontitis were assessed before and after periodontal therapy for Hb, ESR, Erythrocyte count, MCV, MCH, MCHC and PROHEPCIDIN (ELISA).

Results: A significant (p<.000) increase in RBC (4.581) and Hb (12.77) values were estimated after SRP compared to baseline. Prohepcidin levels decreased insignificantly after SRP. Tailed t test results shows significant correlation at the 0.01 level between RBC parameters but no significance between probing depth or prohepcidin values with RBC parameters.

Conclusion: The results conclude that reduction in periodontal inflammation by scaling and ischolar_main planning improves RBC count and hemoglobin level significantly Prohepcidin levels decreases with periodontal treatment but rather insignificantly.

Keywords

Chronic Periodontitis, Prohepcidin, Scaling and Root Planning.

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